[Paper] SIFT-MS: Offering more diluent options in DIMS for pharmaceutical product analysis
Breaking free from the limitations of water dissolution in DIMS to determine residual solvent content in pharmaceutical products
We have developed a more accurate and efficient method for determining the residual solvent content in pharmaceutical products, that allows for a wider variety of solvents without compromising analytical performance.
Quantifying the solvent content in pharmaceutical products often relies on dissolution in a solvent, followed by headspace-gas chromatography. However, when using direct-injection mass spectrometry (DIMS), limited solvent options are available since the instrument is more susceptible to saturation. The use of water is suitable from an instrumentation perspective but is ineffective in the analysis of water-insoluble drugs.
We’re breaking free from the limitations of traditional chromatography with the power of selected ion flow tube mass spectrometry (SIFT-MS). By exploring different solvents like DMAC, DMF, DMI, DMSO, methanol, and triacetin, we’ve discovered exciting possibilities for diluent options. The outcome is a more accurate and efficient form of analysis that doesn’t impact the analytical performance or data produced.
Read our recent study to discover the outcome and benefits of using SIFT-MS to analyse pharmaceutical products. Talk to one of our experts about how this method can be used in various forms of analysis including packaging, food, and consumer products, as well as environmental matrices.