A Fast, Simplified Approach to Quantitative Headspace Analysis of Volatile Impurities in Drug and Packaging Products

Iain Dallas

20th September 2023

Cost-Effective Volatile Impurity Detection with SIFT-MS

Quantifying volatile impurities in condensed-phase samples can be expensive and time-consuming, requiring multiple analyses for each sample. We have found a faster, cheaper way to complete these analyses without the hassle of matrix-matched calibration standards. 

With the power of direct-injection mass spectrometry, specifically in the form of selected ion flow tube mass spectrometry (SIFT-MS), we’ve transformed multiple headspace extraction (MHE) into a cost-effective analytical marvel. Expect lightning-fast headspace analysis, with the added advantage of stable correlation between the first injection and full MHE analysis for weeks on end.

In this article, we show the application of enhanced MHE workflows in real-world scenarios. See how we’ve tackled the analysis of styrene, formaldehyde, and N-nitrosodimethylamine (NDMA) in polystyrene polymer, gelucire excipient, and ranitidine drug products, respectively. Read the article.

Contact us to understand how you could upgrade your analytical processes today with our cutting-edge techniques. Avoid calibration headaches and costly procedures and embrace the future of impurity detection.