AS225: The Use of SIFT-MS to Determine Drying End Points for In-Line Process Monitoring

Martin Perkins

18th June 2019

The Use of SIFT-MS to Determine Drying End Points for In-Line Process Monitoring:

Organic solvents are widely used in the production of active pharmaceutical ingredients (API), however, their presence in the final product needs to be carefully controlled and as low as is reasonably possible. Solvent drying processes are therefore of particular interest to continuous pharmaceutical manufacturing.

This application note describes the use of Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) as a probe to measure the end point of a supercritical CO2 extraction technique for drying paracetamol.

The data presented shows good sensitivity and allows measurements beyond the traditional gravimetric approaches.

The ability to generate data is extremely beneficial since it allows immediate control of the processes used in continuous API manufacturing.

**********************

Anatune Application Notes:

Anatune (and our partners) regularly produce Application Notes. These cover a wide and diverse range of methods, techniques, applications, and related chromatography technology. Our Application Notes provide detailed technical information, unique applications insight and method development & validation, as well as systems configuration innovations to ensure readers can further their knowledge in an engaging way. For many years, Anatune’s Application Notes have helped and supported analytical chemists in the fields of Gas Chromatography – GC, Liquid Chromatography – LC, and Mass Spectrometry – MS achieve to develop analytical solutions. Visit our Applications Note page to search for the insight you need in the following categories: Matrix, Technique, Analyte, Instruments, Product, Industry. Or alternatively, CONTACT US for more information or to put forward an Application Note subject and our Applications Team will be happy to support you in any way they can.