AS133: Method Development Considerations for Automated Headspace Solvent MicroExtraction (aHSME) Using a GERSTEL MultiPurpose Sampler (MPS2)
Method Development Considerations for Automated Headspace Solvent MicroExtraction (aHSME) Using a GERSTEL MultiPurpose Sampler (MPS2):
The need for increased sensitivity and selectivity is a constant challenge facing many industries.
Single Drop MicroExtraction (SDME) is a technique suitable for a variety of sample types and matrices.
SDME involves suspending a microdrop of solvent from the tip of a syringe in the sample container. Analytes migrate into the solvent resulting in an enriched sample that can be retracted back into the syringe and injected directly onto a Gas Chromatography or Liquid Chromatography system for analysis.
This application note describes the automated headspace solvent microextraction and optimisation of solvent choice and sample temperature for the analysis of common leachable chemicals in pharmaceutical products. The analysis showed reasonable repeatability with %rsd of <18 (n=6) for the 23 tested analytes.
Element Application Notes:
Element (and our partners) regularly produce Application Notes. These cover a wide and diverse range of methods, techniques, applications, and related chromatography technology. Our Application Notes provide detailed technical information, unique applications insight and method development & validation, as well as systems configuration innovations to ensure readers can further their knowledge in an engaging way. For many years, Element’s Application Notes have helped and supported analytical chemists in the fields of Gas Chromatography – GC, Liquid Chromatography – LC, and Mass Spectrometry – MS achieve to develop analytical solutions. Visit our Applications Note page to search for the insight you need in the following categories: Matrix, Technique, Analyte, Instruments, Product, Industry. Or alternatively, CONTACT US for more information or to put forward an Application Note subject and our Applications Team will be happy to support you in any way they can.
Before you download...
Please enter your email address before downloading this document.