Method Development Considerations for Automated Headspace Solvent MicroExtraction (aHSME) Using a GERSTEL MultiPurpose Sampler (MPS2)

Martin Perkins

11th September 2019


The need for increased sensitivity and selectivity is a constant challenge facing many industries.  Single Drop MicroExtraction (SDME) is a technique suitable for a variety of sample types and matrices.  SDME involves suspending a microdrop of solvent from the tip of a syringe in the sample container.  Analytes migrate into the solvent resulting in an enriched sample that can be retracted back into the syringe and injected directly onto a Gas Chromatography or Liquid Chromatography system for analysis.

This application note describes the optimisation of solvent choice and sample temperature for the analysis of common leachable chemicals in pharmaceutical products.  The analysis showed reasonable repeatability with %rsd of <18 (n=6) for the 23 tested analytes.

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