NEW PAPER PUBLISHED: Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma
Syft Technologies – SIFT-MS Instrumentation
Colin Hastie, one of Anatune’s key Application Chemists, has been working on a ground-breaking piece of work alongside the University of Edinburgh and it has recently been published. Titled Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma, the research proved how SIFT-MS has emerged as crucial part of an analysts toolkit.
Read on to find out more about the work and Colin’s career to date:
Self-poisoning with professional agricultural pesticide products is responsible for about 20% of global suicide, with most cases occurring in South Asia and China. Treatment of severe poisoning involves long-term intensive clinical care and is often unsuccessful.
Solvent co-formulants (such as cyclohexanone) also contribute to mortality themselves or via more toxic metabolic products (such as cyclohexanol).
Faster detection of co-formulants could aid earlier identification of pesticide poisoning and faster intervention, reducing mortality. Conventional analysis of volatiles in blood uses headspace (HS)-GC/MS.
This paper evaluates SIFT-MS, a direct MS technique that provides higher sample throughput than GC/MS, as a potential tool for cyclohexanone and cyclohexanol analysis in plasma. Both instruments were calibrated using a conventional approach prior to analysis of each porcine plasma sample on both instruments.
Comparative data were evaluated using Bland−Altman plots, demonstrating that the techniques were in good agreement. Compared with GC/MS, SIFT-MS provides fourfold higher sample throughput and shows great promise as an alternative analytical tool.
DOWNLOAD the full Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma research below:
Colin Hastie, Anatune Application Chemist
“I graduated from the University of Strathclyde with a MSc degree in forensic and analytical Chemistry, and completed a part time PhD from the environment centre of Lancaster University using passive samplers to allow aqueous monitoring.
Following this, I was an analytical chemist in Unilever safety and environmental assurance centre, predominantly providing analytical solutions to facilitate environmental risk assessment, utilising GC/MS and LC/MS.
I joined Anatune in September 2018 in the role of Applications Chemist, and I currently specialise in both SIFT-MS and GC/MS products.”