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NEW PAPER PUBLISHED: Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma

Anatune

29th November 2021

gas chromatography/mass spectrometry, GC-MS, GC/MS, Selected Ion Flow Tube Mass Spectrometry, SIFT-MS,


syft, technologies, SIFT-MS, TD-SIFT-MS, high-throughput,

Syft Technologies – SIFT-MS Instrumentation

Colin Hastie, one of Anatune’s key Application Chemists, has been working on a ground-breaking piece of work alongside the University of Edinburgh and it has recently been published. Titled Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma, the research proved how SIFT-MS has emerged as crucial part of an analysts toolkit.

Read on to find out more about the work and Colin’s career to date:

 

Abstract

Self-poisoning with professional agricultural pesticide products is responsible for about 20% of global suicide, with most cases occurring in South Asia and China. Treatment of severe poisoning involves long-term intensive clinical care and is often unsuccessful.

Solvent co-formulants (such as cyclohexanone) also contribute to mortality themselves or via more toxic metabolic products (such as cyclohexanol).

Faster detection of co-formulants could aid earlier identification of pesticide poisoning and faster intervention, reducing mortality. Conventional analysis of volatiles in blood uses headspace (HS)-GC/MS.

This paper evaluates SIFT-MS, a direct MS technique that provides higher sample throughput than GC/MS, as a potential tool for cyclohexanone and cyclohexanol analysis in plasma. Both instruments were calibrated using a conventional approach prior to analysis of each porcine plasma sample on both instruments.

Comparative data were evaluated using Bland−Altman plots, demonstrating that the techniques were in good agreement. Compared with GC/MS, SIFT-MS provides fourfold higher sample throughput and shows great promise as an alternative analytical tool.

DOWNLOAD the full Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma research below:

Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography:Mass Spectrometry (GC:MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma

 

colin, hastie, applications, chemist

Colin Hastie, Anatune Application Chemist

“I graduated from the University of Strathclyde with a MSc degree in forensic and analytical Chemistry, and completed a part time PhD from the environment centre of Lancaster University using passive samplers to allow aqueous monitoring.

Following this, I was an analytical chemist in Unilever safety and environmental assurance centre, predominantly providing analytical solutions to facilitate environmental risk assessment, utilising GC/MS and LC/MS.

I joined Anatune in September 2018 in the role of Applications Chemist, and I currently specialise in both SIFT-MS and GC/MS products.”

 

CONTACT US for more information about SIFT-MS and our range of GC/MS solutions. 

CLICK HERE to view Syft Technologies SIFT-MS instrumentation