AS204: Automated Liquid-Liquid Extraction of Epichlorohydrin Using GC-MS

Martin Perkins

10th October 2018

Automated Liquid-Liquid Extraction of Epichlorohydrin Using GC-MS:

Epichlorohydrin; a chemical used in the manufacturing of plastics, polymers and resins can leach into the water supply and is subject to a maximum guideline value in drinking water. Epichlorohydrin is classified as a probable or likely carcinogen in humans.

A typical method employed is manual liquid-liquid extraction, which is a time consuming and laborious process with the potential for poor reproducibility.

By working with ALS Environmental, it was identified that automating the process could overcome these problems. The work outlined in this application note was performed at ALS Environmental using the GERSTEL MPS with agitator (MVorx) and Solvent Safe CF200 Centrifuge.

The use of high recovery vials allows for better enrichment of analytes, as a smaller volume of extraction solvent can be used. The method has been validated to NS30 for drinking water with a recovery of 104% (at 8 µg/L) and an RSD of <5%, showing a large improvement in the manual procedure.

**********************

Element Application Notes:

Element (and our partners) regularly produce Application Notes. These cover a wide and diverse range of methods, techniques, applications, and related chromatography technology. Our Application Notes provide detailed technical information, unique applications insight and method development & validation, as well as systems configuration innovations to ensure readers can further their knowledge in an engaging way. For many years, Element’s Application Notes have helped and supported analytical chemists in the fields of Gas Chromatography – GC, Liquid Chromatography – LC, and Mass Spectrometry – MS achieve to develop analytical solutions. Visit our Applications Note page to search for the insight you need in the following categories: Matrix, Technique, Analyte, Instruments, Product, Industry. Or alternatively, CONTACT US for more information or to put forward an Application Note subject and our Applications Team will be happy to support you in any way they can.